Enasidenib CAS:1446502-11-9
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China Mainland
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1
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place of origin:
China (Mainland)
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Product Detail
CAS NO. | 1446502-11-9 | |
Product Name | Enasidenib | |
Synonyms | AG-221 | |
Formula | C19H17F6N7O | |
Molecular Weight | 473.14 | |
Spec / Purity | 98%min | |
Supply Capacity | ||
Details | Enasidenib, aslo known as AG-221 and CC-90007, is a potent and selective IDH2 inhibitor with potential anticancer activity (IDH2 = Isocitrate dehydrogenase 2). The mutations of IDH2 present in certain cancer cells result in a new ability of the enzyme to catalyze the NAPH-dependent reduction of a-ketoglutarate to R(-)-2-hydroxyglutarate (2HG). The production of 2HG is believed to contribute to the formation and progression of cancer . The inhibition of mutant IDH2 and its neoactivity is therefore a potential therapeutic treatment for cancer. |
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